Tyrosine Power
Tyrosine Power - General Information
A non-essential amino acid. In animals it is synthesized from phenylalanine. It is also the precursor of epinephrine; thyroid hormones; and melanin. [PubChem]
Pharmacology of Tyrosine Power
Tyrosine is a nonessential amino acid synthesized in the body from phenylalanine. Tyrosine is critical for the production of the body's proteins, enzymes and muscle tissue. Tyrosine is a precursor to the neurotransmitters norepinephrine and dopamine. It can act as a mood elevator and an anti-depressant. It may improve memory and increase mental alertness. Tyrosine aids in the production of melanin and plays a critical role in the production of thyroxin (thyroid hormones). Tyrosine deficiencies are manifested by hypothyroidism, low blood pressure and low body temperature. Supplemental tyrosine has been used to reduce stress and combat narcolepsy and chronic fatigue.
Tyrosine Power for patients
Pregnant women and nursing mothers should avoid supplementation with L-tyrosine.
Those with hypertension should exercise caution in the use of L-tyrosine.
Those with melanoma should avoid L-tyrosine supplements.
Tyrosine Power Interactions
Non-selective MAO inhibitors including tranylcypromine sulfate, phenelzine sulfate, and pargyline HC1: Concomitant use of L-tyrosine and non-selective MAO inhibitors may cause hypertension.
Tyrosine Power Contraindications
L-tyrosine is contraindicated:
• In those with the inborn errors of metabolism alkaptonuria and tyrosinemia type I and type II.
• In those taking non-selective monoamine oxidase (MAO) inhibitors.
• In those hypersensitive to any component of an L-tyrosine-containing supplement.
Additional information about Tyrosine Power
Tyrosine Power Indication: Tyrosine is claimed to act as an effective antidepressant, however results are mixed. Tyrosine has also been claimed to reduce stress and combat narcolepsy and chronic fatigue, however these claims have been refuted by some studies.
Mechanism Of Action: Tyrosine is produced in cells by hydroxylating the essential amino acid phenylalanine. This relationship is much like that between cysteine and methionine. Half of the phenylalanine required goes into the production of tyrosine; if the diet is rich in tyrosine itself, the requirements for phenylalanine are reduced by about 50%. The mechanism of L-tyrosine's antidepressant activity can be accounted for by the precursor role of L-tyrosine in the synthesis of the neurotransmitters norepinephrine and dopamine. Elevated brain norepinephrine and dopamine levels are thought to be associated with antidepressant effects.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: L-Tyrosine
Synonyms: 2-Amino-3-(p-hydroxyphenyl)propionic acid; 3-(p-Hydroxyphenyl)alanine; Free-Form L-Tyrosine
Drug Category: Dietary supplement; Micronutrient; Non-Essential Amino Acids
Drug Type: Small Molecule; Nutraceutical; Approved
Other Brand Names containing L-Tyrosine: Rxosine; Tyrosine; Tyrosine Power;
Absorption: L-tyrosine is absorbed from the small intestine by a sodium-dependent active transport process.
Toxicity (Overdose): L-Tyrosine has very low toxicity. There have been very few reports of toxicity. LD50 (oral, rat) > 5110 mg/kg.
Protein Binding: Not Available
Biotransformation: In the liver, L-tyrosine is involved in a number of biochemical reactions, including protein synthesis and oxidative catabolic reactions. L-tyrosine that is not metabolized in the liver is distributed via the systemic circulation to the various tissues of the body.
Half Life: Not Available
Dosage Forms of Tyrosine Power: Not Available
Chemical IUPAC Name: (2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid
Chemical Formula: C9H11NO3
L-Tyrosine on Wikipedia: https://en.wikipedia.org/wiki/L-Tyrosine
Organisms Affected: Humans and other mammals
